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1985/07/16
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Calcium-dependent interactions of an ionophore A23187 with calmodulin.

Inagaki M, Tanaka T, Sasaki Y, Hidaka H.
Biochem Biophys Res Commun. 1985 Jul 16;130(1):200-6.

Abstract

We found that ionophore A23187 interacted reversibly with calmodulin (CaM), in a calcium-dependent fashion. It was found that A23187 interacts selectively with CaM, among calcium binding proteins (such as troponin C and S-100 protein) and other proteins. However, apparently differing from W-7, A23187 did not suppress CaM-dependent enzyme activity such as myosin light chain kinase and Ca2+-dependent cyclic nucleotide phosphodiesterase. Our observations suggest that there are novel calcium-dependent regions of CaM which can be monitored using ionophore A23187 and may not be related to enzyme activation.

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