MZT(株)ゼブラフィッシュ創薬研究所

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最近の記事

2021/02/16
ゼブラフィッシュ論文のみが増加し続けている。
2021/01/13
ゼブラフィッシュ成魚3D行動解析は、新興前夜にある。
2021/01/01
2021年の次世代ゼブラフィッシュ創薬
2020/06/08
phenomics-based drug discovery
2020/05/26
Zebrafish-Based Precision Oncology
2020/05/25
Zebrafish-Based Phenotype Screening
2020/05/23
phenomicsはzebrafishにより爆発する。
2020/02/21
High-Throughput Cardiotoxicity Screening System for Onco-Cardiology
2020/02/13
zebrafish-based onco-cardiology
2020/01/01
次世代プレシジョンメディシン元年

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2018/11/07
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phenomic screening by Dravet syndrome zebrafish model

Epilepsy is a common chronic neurological disease affecting almost 1 million people in Japan and 50 million people worldwide. Despite availability of more than two dozen FDA-approved antiepileptic drugs, one-third of patients fail to receive adequate seizure control. Specifically, pediatric genetic epilepsies are often the most severe, debilitating and pharmaco-resistant forms of epilepsy.
The discovery of epilepsy associated genes suggests varied underlying pathologies and opens the door for development of precision medicine for each genetic epilepsy. Over 80% of patients diagnosed with Dravet syndrome carry a de novo mutation within the voltage-gated sodium channel gene SCN1A and these patients suffer with drug resistant and life-threatening seizures. Here we have developed zebrafish models for Dravet syndrome featuring inactivation of SCN1A with an emphasis on phenomics. we will also report recent drug screening efforts using our models with a focus on assay protocols and predictive pharmacological profiles. As the discovery and development phase rapidly moves from the lab-to-the-clinic for Dravet syndrome, it is hoped that this zebrafish-based drug discovery strategy offers a platform for how to approach any genetic epilepsy.

関連リンク

  • 三重大学大学院医学系研究科システムズ薬理学
  • 三重大学メディカルゼブラフィッシュ研究センター