最近の記事
- 2024/11/07
- ２１世紀におけるゼブラフィッシュ創薬のグローバル展開
- 2024/10/25
- AIDXゼブラフィッシュ創薬のグローバル展開
- 2024/10/15
- 三重大学大学院システムズ薬理学の展開
- 2024/10/05
- システムズ薬理学大学院大募集中です。
- 2024/09/10
- Zebrafish-Based Oncocardionephrology
- 2024/07/01
- ゼブラフィシュによる患者がん移植モデルの個別化医療戦略
- 2024/06/20
- 世界最強のハイスループット個別化 in vivo 蛋白尿スクリーニングシステム
- 2024/06/10
- 紅麹菌によるゼブラフィッシュ蛋白尿
- 2024/06/06
- DXAIゼブラフィッシュ創薬の新しい展開
| 2019/02/14 |
|
Frontiers in Systems Pharmacogy
Systems Pharmacology
https://zqsp-mie-u.org
The Systems Pharmacology of Mie University has particular strengths in the areas of zebrafish-based drug discovery and precision medicine.
Systems pharmacology is defined to identify the gene clusters which are involved in determining the responsiveness and to distinguish responders and non-responders to a given drug. Genome sequencing, transcriptome, proteome, metabolome and phenome analysis are of particular significance in systems pharmacology. Sequencing is used to locate polymorphisms, and monitoring of functional gene expression can provide clue about the genomic response to disease and treatment. The transcriptome analysis can be done by methods of differential hybridization (cDNA microarray, oligomicrochip et al.) and RNA seq. We used transcriptome/proteome/metabolome/phenome analysis to identify therapeutic target genes by studying change of gene expression in animal models(zebrafish) and patient-derived xenograft zebrafish model of various diseases and found novel drug target candidates through this systems pharmacological strategy. The systems pharmacology has the potential for strategy to define novel drug targets in various diseases and holds the promise that drugs might be precision medicine for each individual patient.
J. Pharmacol Tox Met. 96:34, 2019, IJMS in press, 2019, Heliyon 3(3): e00266, 2017, J. Clin.Invest.104:59-66,1999, Frontiers in Pharmacol. 7:162, 2016, Frontiers in Pharmacol. 7:206, 2016, Frontiers in Pharmacol. 7:142, 2016, J. Cardiovasc. Pharm.36,S1-S4,2000, J.Biol.Chem. 276,19921-19928, 2001, Pharmacogenomics J.3,183-188,2003, Circulation;110(13):1839-1846 2004, Nutr Metab (Lond). 20;12:17, 2015, Biomaterials.2015, 52:14-25, Toxicol Sci. 143(2):374-84, 2015, FEBS Letters 588:3409, 2014, PLoS One. 15;9(1):e85439, 2014, ACS Chem. Neurosci., 4 (8), 1183-8211;11932013, Molecular Biotechnology 55:131-142, 2013, PLoS ONE 7(12): e52549, BMC Neuroscience 11:116,2010, BMC Physiology10:21, 2010,
関連リンク
- Department of Systems Pharmacology Mie University Graduate School of Medicine
- Mie University Medical Zebrafish Research Center
関連ファイル
