最近の記事
- 2021/02/16
- ゼブラフィッシュ論文のみが増加し続けている。
- 2021/01/13
- ゼブラフィッシュ成魚3D行動解析は、新興前夜にある。
- 2021/01/01
- ２０２１年の次世代ゼブラフィッシュ創薬
- 2020/06/08
- phenomics-based drug discovery
- 2020/05/26
- Zebrafish-Based Precision Oncology
- 2020/05/25
- Zebrafish-Based Phenotype Screening
- 2020/05/23
- phenomicsはzebrafishにより爆発する。
- 2020/02/13
- zebrafish-based onco-cardiology
- 2020/01/01
- 次世代プレシジョンメディシン元年
| 2014/12/10 |
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Next Generation Zebrafish-Driven Drug Discovery System and Personalized Medicine
We have developed zebrafish-based quantitative and systems pharmacology, which synergistically combine the desirable features of systems pharmacology and emerging technology of zebrafish-based screening system for functional omics and chemical biology. Zebrafish-based systems pharmacology that analyze in vivo regulatory networks involved in drug action can account for a drug’s multiple targets and for the effects of genomic, epigenomic, and posttranslational changes on the drug efficacy. The next generation discipline of systems pharmacology aims to combine experimental analysis and computational modeling of in vivo networks with quantitative pharmacology approaches to drive the drug discovery processes, predict rare adverse events, and catalyze the practice of personalized medicine. This new systems pharmacology can drive drug discovery and personalized medicine.
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