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phenomic screening by Dravet syndrome zebrafish model

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Next Generation Zebrafish-Driven Drug Discovery System and Personalized Medicine

We have developed zebrafish-based quantitative and systems pharmacology, which synergistically combine the desirable features of systems pharmacology and emerging technology of zebrafish-based screening system for functional omics and chemical biology. Zebrafish-based systems pharmacology that analyze in vivo regulatory networks involved in drug action can account for a drug’s multiple targets and for the effects of genomic, epigenomic, and posttranslational changes on the drug efficacy. The next generation discipline of systems pharmacology aims to combine experimental analysis and computational modeling of in vivo networks with quantitative pharmacology approaches to drive the drug discovery processes, predict rare adverse events, and catalyze the practice of personalized medicine. This new systems pharmacology can drive drug discovery and personalized medicine.

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