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2019/08/27
患者がん移植ゼブラフィッシュモデル（PDXZ） への展開
2019/07/25
次世代ゼブラフィッシュ創薬へのイノベーション
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次世代プレシジョンメディシンNext Generation Precision Medicine
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患者がん移植ゼブラフィッシュモデル(PDXZ)の展開
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プレシジョンメディシンの急激な発展
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Dravet 症候群ゼブラフィッシュモデルによる抗てんかん薬in vivoフェノミックスクリーニングシステム
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Clinical Implication of Zebrafish-Based Developmental Toxicology
2019/02/14
Frontiers in Systems Pharmacogy

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Next Generation Zebrafish-Driven Drug Discovery System and Personalized Medicine

We have developed zebrafish-based quantitative and systems pharmacology, which synergistically combine the desirable features of systems pharmacology and emerging technology of zebrafish-based screening system for functional omics and chemical biology. Zebrafish-based systems pharmacology that analyze in vivo regulatory networks involved in drug action can account for a drug’s multiple targets and for the effects of genomic, epigenomic, and posttranslational changes on the drug efficacy. The next generation discipline of systems pharmacology aims to combine experimental analysis and computational modeling of in vivo networks with quantitative pharmacology approaches to drive the drug discovery processes, predict rare adverse events, and catalyze the practice of personalized medicine. This new systems pharmacology can drive drug discovery and personalized medicine.

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