最近の記事
- 2019/02/14
- Frontiers in Systems Pharmacogy
- 2019/02/05
- Patient-Derived Cancer Xenograft-Driven Zebrafish-Based Drug Discovery and Precision Medicine
- 2019/01/01
- 謹賀新年２０１９次世代ゼブラフィッシュ創薬とプレシジョンメディシン
- 2018/12/03
- 腫瘍血管新生のプレシジョンメディシン
- 2018/11/20
- 第４回ゼブラフィッシュ・メダカ創薬研究会基調講演報告
- 2018/10/24
- 次世代ゼブラフィッシュ創薬とプレシジョンメディシン
- 2018/09/11
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- 2018/08/31
- ゼブラフィッシュ創薬とプレシジョン医療
| 2014/12/10 |
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Next Generation Zebrafish-Driven Drug Discovery System and Personalized Medicine
We have developed zebrafish-based quantitative and systems pharmacology, which synergistically combine the desirable features of systems pharmacology and emerging technology of zebrafish-based screening system for functional omics and chemical biology. Zebrafish-based systems pharmacology that analyze in vivo regulatory networks involved in drug action can account for a drug’s multiple targets and for the effects of genomic, epigenomic, and posttranslational changes on the drug efficacy. The next generation discipline of systems pharmacology aims to combine experimental analysis and computational modeling of in vivo networks with quantitative pharmacology approaches to drive the drug discovery processes, predict rare adverse events, and catalyze the practice of personalized medicine. This new systems pharmacology can drive drug discovery and personalized medicine.
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