ゼブラフィッシュ創薬研究所

2024/08/06: Validation of a new protocol for a zebrafish MEFL (malformation or embryo-fetal lethality) test method that conforms to the ICH S5 (R3) guideline.

2024/05/21: In vivo assessment of individual and total proteinuria in zebrafish larvae using the solvatochromic compound ZMB741

2021/10/31: Generation of a Transgenic Zebrafish Line for In Vivo Assessment of Hepatic Apoptosis

2021/08/19: Patient-Derived Cancer Xenograft Zebrafish Model (PDXZ) for Drug Discovery Screening and Personalized Medicine

2021/07/09: Establishment of a Quality Control Protocol for Zebrafish Developmental Toxicity Studies

2020/10/13: Gap junction protein beta 4 plays an important role in cardiac function in humans, rodents, and zebrafish

2020/05/28: A novel orexin antagonist from a natural plant was discovered using zebrafish behavioural analysis

2019/10/15: C3orf70 Is Involved in Neural and Neurobehavioral Development

2019/09/22: Generation of a Triple-Transgenic Zebrafish Line for Assessment of Developmental Neurotoxicity during Neuronal Differentiation

2019/07/17: Aging-associated microstructural deterioration of vertebra in zebrafish

2019/03/18: Zebrafish yolk sac microinjection of thalidomide for assessment of developmental toxicology

2019/02/18: Toxicological Evaluation of SiO2 Nanoparticles by Zebrafish Embryo Toxicity Test

2018/12/27: Increased susceptibility to oxidative stress-induced toxicological evaluation by genetically modified nrf2a-deficient zebrafish.

2018/01/18: EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase

2017/11/23: Chemokines protect vascular smooth muscle cells from cell death induced by cyclic mechanical stretch.

2017/07/29: New photic stimulating system with white light-emitting diodes to elicit electroretinograms from zebrafish larvae.

2017/03/09: Potential protective function of the sterol regulatory element binding factor 1-fatty acid desaturase 12 axis in early-stage age-related macular degeneration

2016/07/11: Activation of Sterol Regulatory Element Binding Factors by Fenofibrate and Gemfibrozil Stimulates Myelination in Zebrafish

2016/06/14: Downregulation of GSTK1 Is a Common Mechanism Underlying Hypertrophic Cardiomyopathy

2016/06/07: Comparative Transcriptome Analysis Identifies CCDC80 as a Novel Gene Associated with Pulmonary Arterial Hypertension

2016/06/06: Establishment of a drug evaluation model against light-induced retinal degeneration using adult pigmented zebrafish

2016/05/19: EP300 Protects from Light-Induced Retinopathy in Zebrafish

2016/04/22: E2F4 Promotes Neuronal Regeneration and Functional Recovery after Spinal Cord Injury in Zebrafish

2016/03/18: Comparative study of the zebrafish embryonic toxicity test and mouse embryonic stem cell test to screen developmental toxicity of human pharmaceutical drugs

2016/01/11: Using zebrafish in systems toxicology for developmental toxicity testing.

2015/12/18: Novel immunologic tolerance of human cancer cell xenotransplants in zebrafish.

2015/12/08: In Vivo Detection of Mitochondrial Dysfunction Induced by Clinical Drugs and Disease-Associated Genes Using a Novel Dye ZMJ214 in Zebrafish

2015/10/13: Pharmacological profiling of zebrafish behavior using chemical and genetic classification of sleep-wake modifiers

2015/09/02: Systems pharmacology of adiposity reveals inhibition of EP300 as a common therapeutic mechanism of caloric restriction and resveratrol for obesity

2015/05/20: E2F8 promotes hepatic steatosis through FABP3 expression in diet-induced obesity in zebrafish.

2015/03/24: In vivo selective imaging and inhibition of leukemia stem-like cells using the fluorescent carbocyanine derivative, DiOC5(3)

2015/03/01: Copper Oxide Nanoparticles Reduce Vasculogenesis in Transgenic Zebrafish Through Down-Regulation of Vascular Endothelial Growth Factor Expression and Induction of Apoptosis

2014/09/11: Zebrafish xenotransplantation model for cancer stem-like cell study and high-throughput screening of inhibitors

2014/08/10: Zinc finger MYND-type containing 8 promotes tumour angiogenesis via induction of vascular endothelial growth factor-A expression

2014/08/07: Effects of Yuzu (Citrus junos Siebold ex Tanaka) peel on the diet-induced obesity in a zebrafish model

2014/01/15: Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis

2014/01/15: Quantitative Phenotyping-Based In Vivo Chemical Screening in a Zebrafish Model of Leukemia Stem Cell Xenotransplantation

2013/11/20: Downregulation of max dimerization protein 3 is involved in decreased visceral adipose tissue by inhibiting adipocyte differentiation in zebrafish and mice.

2013/07/15: S-nitrosylation regulates mitochondrial quality control via activation of parkin.

2013/05/23: Identification of a Novel Indoline Derivative for in Vivo Fluorescent Imaging of Blood-Brain Barrier Disruption in Animal Models.

2013/05/15: Fluorescent-Based Methods for Gene Knockdown and Functional Cardiac Imaging in Zebrafish.

2013/05/13: A Novel, Reliable Method for Repeated Blood Collection from Aquarium Fish.

2013/01/04: A High-Throughput Fluorescence-Based Assay System for Appetite-Regulating Gene and Drug Screening

2012/08/20: SEMA4A mutations lead to susceptibility to light irradiation, oxidative stress, and ER stress in retinal pigment epithelial cells.

2012/08/16: In vivo assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish

2012/08/07: Green tea extract suppresses adiposity and affects the expression of lipid metabolism genes in diet-induced obese zebrafish

2011/12/19: A Novel Protocol for the Oral Administration of Test Chemicals to Adult Zebrafish

2011/12/13: Transcriptome analysis of anti-fatty liver action by Campari tomato using a zebrafish diet-induced obesity model.

2011/05/11: DEVELOPMENT OF ZEBRAFISH-BASED ASSAYS FOR THE ASSESSMENT OF DNT CAUSED BY EXPOSURE TO CHEMICALS AT LOW DOSES

2010/10/21: Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity

2010/09/15: In vivo imaging of zebrafish retinal cells using fluorescent coumarin derivatives

2010/01/01: CCDC132 is highly expressed in atopic dermatitis T cell

2009/10/12: Synergistic induction of heme oxygenase-1 by nicaraven after subarachnoid hemorrhage to prevent delayed cerebral vasospasm.

2009/06/18: Zebrafish beta-adrenergic receptor mRNA expression and control of pigmentation.

2008/05/01: Pharmacogenomics of cardiovascular pharmacology: pharmacogenomic network of cardiovascular disease models.

2008/02/29: Guinea pig cysteinyl leukotriene receptor 2 (gpCysLT2) mediates cell proliferation and intracellular calcium mobilization by LTC4 and LTD4.

2007/01/01: Phosphodiesterase and Intracellular Signaling

2006/12/08: Novel reciprocal regulation of cAMP signaling and apoptosis by orphan G-protein-coupled receptor GPRC5A gene expression.

2005/01/01: Rapid and stable buffer exchange system using InSitu Chip suitable for multicolor and large-scale whole-mount analyses.

2004/01/01: Changes in Cyclic Nucleotide Phosphodiesterase Activity and Calmodulin Concentration in Heart Muscle of Cardiomyopathic Hamsters.

2004/01/01: Potential role for heat shock protein 72 in antagonizing cerebral vasospasm after rat subarachnoid hemorrhage.

2003/01/01: Target validation in hypoxia-induced vascular remodeling using transcriptome/metabolome analysis.

2002/01/01: Identification of highly expressed genes in peripheral blood T cells from patients with atopic dermatitis.

2002/01/01: Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients.

2002/01/01: Genomic organization,chromosomal localization,and alternative splicing of the human phosphodiesterase 8B gene.

2001/01/01: Molecular Cloning of Novel Mouse and Human Putative Citrate Lyase.

2001/01/01: Calcium-dependent Activation of NFIL3/E4BP4 Gene Expression by Calcineurin/NFAT and CaM kinase Signaling.

2001/01/01: Loss of nuclear localization of the S100C protein in immortalized human fibroblasts.

2001/01/01: The Functional Significance of Heme Oxygenase-1 Gene Induction in a Rat Vasospasm Model.

2000/01/07: Ca2+-dependent Inhibition of Actin-activated Myosin Atpase Activity by S100C(S100A11), A Novel Member of the S100 Protein Family.

2000/01/07: Phosphorylation sites by protein kinase C and functional domain of smooth muscle calponin. Kyoto Symposia on Bioscience, VII.

2000/01/01: Automated DNA fragment collection by capillary array gel electrophoresis in search of differentially expressed genes.

2000/01/01: Pharmacogenomics and therapeutic target validation in cerebral vasospasm.

2000/01/01: Calcium-dependent Translocation of S100A11 Requires Tubulin Filaments.

2000/01/01: Relationship between contact inhibition and intranuclear S100C of normal human fibroblasts.

2000/01/01: Transcriptional and post-transcriptional regulation of monocyte chemoattractant protein-3 gene expression in human endothelial cells by phorbol ester and cAMP signalling.

2000/01/01: Ca2+-dependent Inhibition of Actin-activated Myosin Atpase Activity by S100C(S100A11), A Novel Member of the S100 Protein Family.

1999/01/01: Human S100A11 Exhibits Differential Steady-State RNA Levels in Various Tissues and Distinct Subcellular Localization.

1999/01/01: Heme Oxygenase-1 Gene Induction as an Intrinsic Regulation against Delayed Cerebral Vasospasm in Rats.

1999/01/01: Regulatory Mechanisms of Calponin Phosphorylation in Endothelin-1-induced Contraction of Porcine Coronary Artery.

1999/01/01: Molecular Cloning and Characterization of Mammalian Homologues of Vesicle-Associated Membrane Protein-Associated (VAMP-Associated) Proteins.

1998/12/13: Overexpression of caltractin gene in Tumor-Infiltrating Lymphocytes.

1998/02/24: A Unique Exon-intron Organization of a Porcine S100C Gene: Close Evolutionary Relationship to Calmodulin Genes.

1998/01/15: Two distinct actin-binding sites of smooth muscle calponin.

1997/08/20: Propiverine Hydrochloride, Anti-Pollakiuric Agent, inhibits the Activity of Actomyosin ATPase from the Urinary Bladder.

1997/01/13: QM Is a Novel Zinc-Binding Transcription Regulatory Protein : Its Binding to c-Jun Is Regulated by Zunc Ions and Phosphorylation by Protein Kinase C.

1996/03/27: Novel Specific Chemotactic Receptor for S100L Protein on Guinea Pig Eosinophils.

1995/09/01: A Calponin Peptide Enhances Ca2+ Sensivity of Smooth Muscle Contraction without Affecting Myosin Light Chain Phosphorylation

1995/05/25: Protein Kinase C-Independent Activation of Raf-1 and Mitogen-Activated Protein Kinase by Leukotriene B4 in Guinea Pig Eosinophils

1995/03/08: Phosphorylation of Calponin Mediated by Protein Kinase C in Association with Contraction in Porcine Coronary Artery

1995/01/01: Inhibition by wortmannin of M-current in bullfrog sympathetic neurones

1994/12/02: Characterization of the Myosin-binding Subunit of Smooth Muscle Myosin Phosphatase

1994/09/29: Purification and characterization of a novel calcium-binding protein, S100C, from porcine heart

1994/09/01: Identification and characterization of isoenzymes of cyclic nucleotide phosphodiesterase in human kidney and heart, and the effects of new cardiotonic agents on these isoenzymes.

1994/02/01: Separation and characterization of a novel isoenzyme of cyclic nucleotide phosphodieterase from rat cerebrum. .

1993/12/11: Myosin Light Chain Kinase Occurs in Bullfrog Sympathetic Neurons and May Modulate Voltage-Dependent Potassium Currents.

1993/06/30: Calponin phosphatase from smooth muscle : A possible role of type 1 protein phosphatase in smooth muscle relaxation.

1993/03/25: Identification of the regulatory site in smooth muscle calponin that is phosphorylated by protein kinase C.

1993/01/29: Two isoforms of cGMP-inhibited cyclic nucleotide phosphodiesterases in human tissues distinguished by their responses to vesnarinone, a new cardiotonic agent.

1992/12/07: Inhibition of actin-activated myosin Mg2+-ATPase in smooth muscle by ruthenium red.

1992/10/25: Ruthenium red inhibits the binding of calcium to calmodulin required for enzyme activation

1992/09/01: Cardiac sarcoplasmic reticulum chloride channels regulated by protein kinase A.

1992/01/01: Cyclic AMP Phosphodiesterase from human heart and drug action.

1991/12/16: Molecular cloning and expression of the cDNA coding for a new member of the S100 protein family from porcine cardiac muscle.

1991/10/01: The catalytic subunit of cyclic AMP-dependent protein kinase directly inhibits sodium channel activities in guinea-pig ventricular myocytes.

1990/09/28: Modulation of smooth muscle calponin by protein kinase C and calmodulin.

1990/05/31: Effects of ruthenium red on activation of Ca2+-dependent cyclic nucleotide phosphodiesterase.

1990/03/30: Phosphorylation of high-Mr caldesmon by protein kinase C modulates the regulatory function of this protein on the interaction between actin and myosin.

1990/02/15: Effects of amrinone and enoximone on the subclasses of cyclic AMP phosphodiesterase from human heart and kideny.

1989/11/15: Selective low level of protein kinase C isozyme in a tumor promoter-dependent mouse leukemia cell line.

1989/07/01: Monoclonal antibody assessment of tissue- and species-specific myosin light chain kinase isozymes..

1989/01/01: S-100 antigen and calmodulin in human leukemic cells.

1989/01/01: Molecular properties of calcium-binding proteins from bovine cardiac muscle.

1989/01/01: Calcium signaling of calcium-binding proteins and drug actions.

1988/09/01: Immunocytochemical evidence for translocation of protein kinase C in human megakaryoblastic leukemic cells : Synergistic effects of Ca2+ and activators of protein kinase C on the plasma membrane association.

1988/08/01: Differential effects of flavonoids as inhibitors of tyrosine protein kinases and serine /threonine protein kinases.

1988/07/01: Inhibition of human platelet secretion and of Ca2+, calmodulin-dependent protein phosphorylation by the antiallergic agent, GMCHA.

1988/07/01: Putative binding site(s) of 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7) on protein kinase C.

1988/05/15: Selective inhibition of cyclic AMP phosphodiesterase from various human tissues by milrinone, a potent cardiac bipyridine.

1988/05/15: Selective inhibition of cyclic AMP phosphodiesterase from various human tissues by milrinone, a potent cardiac bipyridine.

1988/05/05: Modulation of tyrosine phosphorylation of p36 and other substrates by the S-100 protein.

1988/04/05: Cell type-specific expression of protein kinase C isozymes in the rabbit cerebellum.

1988/02/01: Calmodulin-dependent calcium signal transduction.

1988/01/01: Effects of cilostazol, a selective cAMP phosphodiesterase inhibitor on the contraction of vascular smooth muscle..

1988/01/01: Selective inhibitors of calmodulin-dependent phosphodiesterase and other enzymes.

1988/01/01: Ca2+, phospholipid and Ca2+, calmodulin-dependent myosin light chain phosphorylation of smooth muscle and nonmuscle cells.

1987/11/13: Different sensitivities of Ca2+, calmodulin-dependent cyclic nucleotide phosphodiesterases from rabbit aorta and brain to dihydropyridine calcium channel blockers.

1987/07/01: Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives.

1987/06/30: The Ca2+-activated protease (Calpain) modulates Ca2+/calmodulin dependent activity of smooth muscle myosin light chain kinase.

1987/01/01: Isolation and structural analysis of the chromosomal gene for chicken calmodulin.

1987/01/01: Transmembrane Ca2+ signaling and a new class of inhibitors.

1986/11/28: N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide is one of a new class of activators for Ca2+-activated, phospholipid-dependent protein kinase.

1986/11/01: Effect of calmodulin inhibitors on thyroid hormone secretion.

1986/07/29: N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide, a novel activator of protein kinase C.

1986/03/29: Modulation of calmodulin function and of Ca2+-induced smooth muscle contraction by the calmodulin antagonist, HT-74.

1986/01/15: The binding of the calcium channel blocker, bepridil, to calmodulin.

1985/09/10: Ca2+-dependent cyclic nucleotide phosphodiesterase is activated by poly(L-aspartic acid).

1985/07/16: Calcium-dependent interactions of an ionophore A23187 with calmodulin.

1984/11/01: Purification of cyclic adenosine monophosphate phosphodiesterase from human platelets using new-inhibitor Sepharose chromatography.

1984/01/14: Calcium-dependent hydrophobic chromatography of calmodulin, S-100 protein and troponin-C.

1983/03/01: Calcium-independent activation of calcium ion dependent cyclic nucleotide phosphodiesterase by synthetic compounds: quinazolinesulfonamide derivatives.

1983/01/01: Calmodulin antagonists enhance calcium binding to calmodulin.

1983/01/01: Naphthalenesulfonamides as calmodulin antagonists.

1983/01/01: Calcium-dependent interactions with calmodulin of a fluorescent calmodulin antagonist: N2-dansyl-L-arginine-4-t-butylpiperidine amide.

1982/09/22: Hydrophobic interaction of the Ca2+-calmodulin complex with calmodulin antagonists. Naphthalenesulfonamide derivatives.

1982/09/22: Two types of calcium-dependent protein phosphorylations modulated by calmodulin antagonists. Naphthalenesulfonamide derivatives.

1981/12/10: Calcium-dependent affinity chromatography of S-100 and calmodulin on calmodulin antagonist-coupled Sepharose.

1981/11/20: Activity-structure relationship of calmodulin antagonists, Naphthalenesulfonamide derivatives.

1981/07/30: Interaction of local anesthetics with calmodulin.

1981/07/01: N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation.

1981/04/30: Gonadotropin response to luteinizing hormone releasing hormone in hyperthyroid patients with menstrual disturbances.

1981/01/01: Biopharmacological assessment of calmodulin function: utility of calmodulin antagonist naphthalenesulfonamide.

1980/12/10: Hydrophobic regions function in calmodulin-enzyme(s) interactions.

1980/10/30: Ca2+-calmodulin-dependent phosphorylation and platelet secretion.

1980/08/27: Effect of beta-adrenergic blockade on plasma dopamine-beta-hydroxylase activity and triiodothyronine in hyperthyroidism.

1980/01/17: Calcium-regulated modulator protein interacting agents inhibit smooth muscle calcium-stimulated protein kinase and ATPase.

1980/01/15: Activation of myosin light chain kinase by trypsin.